The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms msk psychiatry pharmacology sideeffects allergic classification definitions differential hypersensitivity inhibitors reactions serotonin types acquired acute alzheimersdisease anticonvulsants
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... causes development ... of allergen-specific ... Allergic reaction ... Stevens-Johnson Syndrome
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Stevens-Johnson Syndrome ... #Allergic #Reactions ... Classification #Diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... Posterior Cord Syndrome ... #diagnosis #pathophysiology ... symptoms #msk #orthopedics
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
leading to an allergic ... cell surfaces causes ... leading to an allergic ... causes development ... Classification #Diagnosis
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... Stevens-Johnson Syndrome ... Systemic effect -> Nausea
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
• Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Dizziness - Nausea ... SideEffects #Psychiatry #Diagnosis
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Fractures #msk #orthopedics ... #diagnosis #differential ... #causes #pathophysiology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... Vomiting Serotonin Syndrome ... gain Incr NE: Nausea ... SideEffects #Psychiatry #Diagnosis
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... #CaudaEquina #Syndrome ... pathophysiology #diagnosis
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer's (99% of cases ... Alzheimer's (1% of cases ... mutations - Down syndrome ... pathophysiology #geriatrics #diagnosis
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