The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... as potentially ... lgE Abs persist
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... Plasma Cells -> lgE Abs ... Tissue edema #Allergic
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
Production of lgE Abs ... leading to an allergic ... leading to an allergic ... An allergic reaction ... #Allergic #Reactions
Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
CompartmentSyndrome #ACS ... pathophysiology #orthopedics
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing (and disruptors ... ) • Fracture disrupts ... Healing #Stages #Orthopedics ... pathophysiology #diagnosis #disruptors