The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Orbital Cellulitis: Pathogenesis and Clinical Findings
Definitions:
a. Chemosis: Edema of the bulbar conjunctiva
b. Panopthalmitis: inflammation of all
Orbital Cellulitis ... anterior to the orbital ... #Cellulitis #pathophysiology ... #ophthalmology ... #diagnosis #signs
Periorbital Cellulitis: Pathogenesis and Clinical Findings
Definitions:
a. Dacryoadenitis: infection of the lacrimal glands
b. Conjunctivitis: inflammation of the
Periorbital Cellulitis ... preseptal compartment/orbital ... #pathophysiology ... #ophthalmology ... #diagnosis #signs
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
Cubital Tunnel Syndrome ... Tinel sign over cubital ... CubitalTunnel #Syndrome #Diagnosis ... #pathophysiology ... signs #symptoms #msk
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
red reflex) • Orbital ... Retinoblastoma #pathophysiology ... #ophthalmology ... #diagnosis #signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
side) Second Stage ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages ... #staging #msk
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Hypertension Stage ... -> AV nicking Stage ... #Retinopathy #pathophysiology ... #ophthalmology ... #diagnosis #signs
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
hypercoagulable state ... Hypercoagulable state ... Occlusion #CRAO #pathophysiology ... #ophthalmology ... #diagnosis #signs
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis ... #pathophysiology
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Inflammatory Stage ... site Soft Callus Stage ... #Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
bone formation MSK ... Nephrolithiasis (Kidney Stones ... PagetsDisease #pathophysiology ... #diagnosis #signs