The Calgary Guide to Understanding Disease @TheCalgaryGuide
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signs symptoms complications secondary staging acute adhesivecapsulitis centralretinalartery chronic closedangle comparison crao degenerative disruptors fracture frozenshoulder healing hypertensive inflammatory jointdisease
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
Acute Closed Angle Glaucoma ... present with early glaucoma ... scotomas of various shapes ... #pathophysiology ... #ophthalmology
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
• Secondary glaucoma ... Retinoblastoma #pathophysiology ... #ophthalmology ... #diagnosis #signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
side) Second Stage ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages ... #staging #msk
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
Hypertension Stage ... -> AV nicking Stage ... #Retinopathy #pathophysiology ... #ophthalmology ... #diagnosis #signs
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
hypercoagulable state ... Hypercoagulable state ... Occlusion #CRAO #pathophysiology ... #ophthalmology ... #diagnosis #signs
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis ... #pathophysiology
Secondary Glaucoma: Pathogenesis and Clinical Findings Open-Angle Secondary Glaucoma: • Pre-trabecular defect -> Aqueous outflow is obstructed
Secondary Glaucoma ... Open-Angle Secondary Glaucoma ... defects => End-stage ... #pathophysiology ... #ophthalmology
Primary Open-Angle Glaucoma: Pathogenesis and Clinical Findings • Risk factors -> Incr IOP, Incr age, African-American
Primary Open-Angle Glaucoma ... Primary Open-Angle Glaucoma ... defects => End-stage ... #pathophysiology ... #ophthalmology
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Inflammatory Stage ... site Soft Callus Stage ... #Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
bone formation MSK ... Nephrolithiasis (Kidney Stones ... PagetsDisease #pathophysiology ... #diagnosis #signs
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