The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
and hypothalamic-pituitary-adrenal ... Psychological Symptoms ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Anorexia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: concordance
AnorexiaNervosa #pathophysiology ... #diagnosis #signs ... #symptoms #psychiatry ... #RiskFactors
Bulimia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: Some
BulimiaNervosa #pathophysiology ... #diagnosis #signs ... #symptoms #psychiatry ... #RiskFactors