The Calgary Guide to Understanding Disease @TheCalgaryGuide
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allergy pathophysiology diagnosis hypersensitivityreaction immunology classification complications hypersensitivity reactions signs sle symptoms types erythematosus gastrointestinal manifestations mucocutaneous systemic type1 type2
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... fever, Urticaria, Allergic ... • Ex: Systemic Lupus ... Classification #Diagnosis #Definitions
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
clinical findings Definition ... leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
clinical findings Definition ... mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
clinical findings Definition ... : • Systemic Lupus ... HypersensitivityReaction #Allergy
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Systemic #Lupus
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity: Definitions ... leading to an allergic ... leading to an allergic ... An allergic reaction ... Classification #Diagnosis #Definitions
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Phenomenon #Lupus
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
clinical findings Definition ... HypersensitivityReaction #Allergy
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