The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology allergy immunology diagnosis complications signs sle symptoms classification definitions erythematosus gastrointestinal hypersensitivity manifestations mucocutaneous reactions systemic type1 type2 type3
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... #TypeI #Type1 #HypersensitivityReaction ... #Allergy #Immunology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... fever, Urticaria, Allergic ... • Ex: Systemic Lupus ... #Allergic #Reactions
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... Initial exposure to allergen ... TypeIV #Type4 #HypersensitivityReaction ... #Allergy #Immunology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
: • Systemic Lupus ... TypeIII #Type3 #HypersensitivityReaction ... #Allergy #Immunology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Systemic #Lupus
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Phenomenon #Lupus
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
#Type2 #Type2 #HypersensitivityReaction ... #Allergy #Immunology
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