Ravi Singh K @rav7ks
1.2M 757 370
Academic Hospitalist and Associate Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Hopkins Medicine Clerkship Site Director, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Low Alkaline Phosphatase ... Most cases diagnosed ... nephrocalcinosis • CPPD ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Causes of Orthopnea - Differential Diagnosis Framework

 • Fear and Anxiety
 • Pleural Effusion
 • Ascites
Causes of Orthopnea ... • Ascites • COPD ... • Pulmonary Edema ... Cardiogenic pulmonary edema ... Differential #Diagnosis #Causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... Differential Diagnosis Algorithm ... Bone growth) Alkaline ... Intestine - Other causes ... Differential #Diagnosis #Algorithm
Uncommon Causes of Noncardiogenic Pulmonary Edema (NCPE) - Differential Diagnosis Framework

High Altitude Pulmonary Edema:
 • Accumulation
Uncommon Causes ... epilepticus • Pathophysiology ... : • Pathophysiology ... The predominant pathophysiologic ... • Pathophysiology
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Noncardiogenic Pulmonary Edema ... Framework NCPE Pathophysiology ... Noncardiogenic pulmonary edema ... Causes include: ... of peripheral edema
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... Cause - Decreased ... intoxication Cause ... Differential #Diagnosis #Algorithm ... #Pathophysiology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
matter vasogenic edema ... Etiology: • Pathophysiology ... • Vasogenic edema ... the underlying cause ... with AEDs until cause
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... PBC Labs: • Alkaline
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... Phosphate is a cause ... phosphorus is seen in COPD ... patients with COPD ... respiratory #hypoxia #pathophysiology
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
Manifestations Causes ... - Peripheral edema ... beriberi #nutrition #pathophysiology