Ravi Singh K @rav7ks
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Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
six months of treatment ... of HIV/AIDS patients ... worsening of that disease ... be present: • AIDS ... pericarditis, peritoneal disease
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
Infection in HIV / AIDS ... Antimicrobial treatment ... Demyelinating disease ... differential #diagnosis #AIDS
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
extrapulmonary disease ... or meningitic disease ... yeast • At risk: AIDS ... 40% Invasive Disease ... endocarditis Local Disease
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
and less common diseases ... diagnosis and treatment ... Vogt-Koyanagi-Harada (VKH) disease ... polychondritis • Behcet disease
Lyme Disease - Diagnosis and Management Summary

Lyme Disease Epidemiology:
- Spirochete
- Reservoir: small mammals & birds
- Transmitted
Lyme Disease - Diagnosis ... Summary Lyme Disease ... months Lyme Disease ... Treatment: 1. ... Diagnosis #Management #treatment
Blurry Vision - Differential Diagnosis Framework

Anatomical Approach to Eye Disease:
1. Lids/Lashes
2. Extraocular Muscles/Motility
3. Conjunctiva/Sclera
4. Cornea
5. Anterior
Approach to Eye Disease ... Lids/Lashes 2. ... optic disk • HIV/AIDS
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
• Periodontal disease ... hemorrhage • Treatment ... continue antibiotic treatment ... several months of treatment ... causes #management #treatment
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Syndrome Systemic disease ... Inflammatory eye disease ... • Neurologic Disease ... VTE) • Cardiac Disease ... Arthritis, AS Treatment
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Pregnancy - Renal disease ... granulamatous disease ... - Infiltrative diseases ... Other biliary diseases
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
goiter (Graves' disease ... TRAb) if Graves' disease ... ↑ AST/ALT • Treatment ... tenderness Treatment