Ravi Singh K @rav7ks
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Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... • Progressive lung ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... • Progressive lung ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
polymicrobial infection ... Leukocytosis, anemia ... hemorrhage • Treatment ... several months of treatment ... westermani • Other: TB
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Mycobacteria (NTM) Infections ... infections • ... Kansasii: • Mimics TB ... Bone Marrow - Anemia ... differential #diagnosis #infectiousdiseases
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Neutropenia - recurrent infections ... Idiopathic • Infections ... Treatment: ... #oncology #hematology
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
and bacterial infections ... • Lymphoma • TB ... schistosomiasis • Pyemia ... Night Sweats: • TB ... Brucellosis • Liver or lung
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Lung Infections ... infiltrates, mimicking TB ... 100% of cases), anemia ... #Infections #HIV ... differential #diagnosis #infectiousdiseases
Bronchiectasis - Summary

What?
• Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
: • Recurrent infection ... : TB, NTM, PNA ... in the adjacent lung ... of the affected lung ... mycobacteria Treatment
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
petechiae) • Frequent infections ... • Parvovirus infection ... factor (GCSF) treatments ... marrow studies Treatment ... diagnosis #hematology #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
weeks without infection ... • Neutropenia, anemia ... microglobulin Treatment ... diagnosis #workup #oncology