Ravi Singh K @rav7ks
1.1M 733 353
Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... • Progressive lung ... Treatment: Active ... Initiating Treatment ... #Management #Treatment
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... • Progressive lung ... Treatment: Active ... Initiating Treatment ... #Management #Treatment
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
CNS Infection in ... Antimicrobial treatment ... 80% sensitive Tuberculous ... - Hemorrhage, tuberculomas ... opportunistic #InfectiousDiseases
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Lung Infections ... Lymphadenopathy, CNS ... infiltrates, mimicking TB ... 100% of cases), anemia ... differential #diagnosis #infectiousdiseases
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Mycobacterium tuberculosis ... Kansasii: • Mimics TB ... Bone Marrow - Anemia ... patients with typical tuberculosis ... differential #diagnosis #infectiousdiseases
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
• Lymphoma • TB ... • Disseminated tuberculosis ... Yellow fever • Tuberculous ... Night Sweats: • TB ... Brucellosis • Liver or lung
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
polymicrobial infection ... Leukocytosis, anemia ... hemorrhage • Treatment ... several months of treatment ... westermani • Other: TB
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Prosthetic valves Lung ... pneumonia (late) • Tuberculosis ... Pneumonia • Other lung ... Periodic paralyses CNS ... • Toxins • Infection
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
especially the CNS ... MC: CNS CSF: • ... change in the lungs ... nails, bronchi, lungs ... ) #Mycoses #InfectiousDiseases
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
nervous system (CNS ... rash) • Heart, lung ... SLE], AOSD) • Infection ... with leukopenia, anemia ... Treatment: • Corticosteroids