Ravi Singh K @rav7ks
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Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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diagnosis management hematology differential oncology causes neurology rheumatology disease hiv infectiousdiseases lung pulmonary cardiology classification infections leukemia nutrition workup abscess
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... Treatment: ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Inflammatory and ... Differential #Diagnosis #Hematology
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Summary Acute AIDP ... Guillain-Barre Pathophysiology ... Paresthesias: Hands ... Treatment: • Plasmapheresis ... diagnosis #management #treatment
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Stiff Person Syndrome ... pernicious anemia ... Pathophysiology ... Treatment: • ... Diagnosis #Management #treatment
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... high BANDemia on ... Degree of bandemia ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Gastroesophageal Reflux Disease (GERD) - Summary GERD: Diagnosis • Heartburn (substernal burning sensation) and acid regurgitation • Chest pain Extraesophageal
• Vomiting • Anemia ... Incomplete/relief/treatment ... Alarm features: • Anemia ... of bed GERD Treatment ... diagnosis #management #Gastroenterology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... The clinical syndrome ... Treatment: • HAART ... treatment • Cognitive ... disorder #dementia #AIDS
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
posterior occipital and ... Etiology: • Pathophysiology ... epilepticus Treatment ... underlying cause • Treatment ... Seizures: Treat with AEDs
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