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diagnosis management oncology classification signs vasculitis agglutinin anemia apml arteritis autoantibodies autoimmune chronic cll cold differentiation disease erythematosus gca giantcell
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Lung involvement 3% ... autoantibodies #signs ... #symptoms #mimickers ... #differential # ... rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
affects infants < 3 ... Diagnosis: HLH signs ... and symptoms can ... >500 ng/mL • Elevated ... management #treatment #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 ... Antibodies[PCH] 3. ... Hyperbilirubinemia • Elevated ... younger pts) Differential ... hemolytic #anemia #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
if WBC > 5 or elevated ... • Diagnosis: >3 ... symptoms, or> 1 ... initiation • Differential ... diagnosis #management #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Agranulocytosis 3. ... Elevated LDH 5. ... workup #oncology #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... very remarkable w/differential ... elicited after 2-3 ... slow taper over 1-3 ... them, but urgent rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... or proteinase 3 ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
or proteinase 3 ... Presentation - Systemic Symptoms ... purpura: strong sign ... are proteinase 3 ... #diagnosis #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
ingestion • B symptoms ... in 1/3 of patients ... Inflammatory marker elevated ... Immunohistochemical studies (to differentiate ... classification #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... ) • Shawl sign ... kinase levels are elevated ... Myositis #Myopathy #rheumatology ... #differential #
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