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differential rheumatology algorithm acute aki classification injury kidney management nephrology ana antibodies antibody antineutrophil antinuclear cryoglobulinemia cryoglobulins diseases encephalopathy glomerulonephritis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
• Sjögren syndrome ... Vasculitis: • ... Microscopic polyangiitis ... - MPO>PR3 - ANCA ... Antineutrophil #antibodies #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... -ANCA): • Microscopic ... tract, and often causes ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
- Differential Diagnosis ... Abdominal Compartment Syndrome ... Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... #nephrology #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Negative IF): • PR3 ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... -ANCA)): Microscopic ... tract, and often causes ... • Cogan syndrome
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... vasculitis (AAV ... polyangiitis), MPA (microscopic ... Auto-antibodies: ANCA ... Goodpasture's cause
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Diagnosis: 1. ... circulation: MCA ACA ... the underlying cause ... with AEDs until cause
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