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diagnosis differential nephrology rheumatology causes pulmonary acute aki algorithm antibodies antibody antineutrophil antinuclear blood classification diseases hematuria injury kidney management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... • Sjögren syndrome ... Vasculitis: • ... Microscopic polyangiitis ... vasculitis - MPO
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis, Microscopic ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... , anti-GBM ab, ANA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
renal abnormalities ... ): • Microscopic ... Vasculitis: + MPO-ANCA ... Dx: GPA, EGPA, microscopic ... (Renal involvement
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... Abdominal compartment syndrome ... syndrome: troponin
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... pain hematuria syndrome ... hematuria: - RBC casts ... Diagnostic of GN or vasculitis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... polyangiitis), MPA (microscopic ... Auto-antibodies: ANCA ... FINDINGS: • U/A: microscopic ... hematuria, RBC casts
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
renal abnormalities ... : ANCA Associated ... Pauci Immune (ANCA ... )): Microscopic ... No Granulomas (ANCA
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