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diagnosis nephrology rheumatology causes pulmonary urine acute aki algorithm ana anca antibodies antibody antineutrophil antinuclear blood classification fever hematology hematuria
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
Atlas of Urine Microscopy ... fresh at time of microscopy ... renal disease ... • “Muddy brown cast ... #Atlas #key #diagnosis
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria - Differential ... basement membrane disease ... hematuria: - RBC casts ... Diagnostic of GN or vasculitis ... of glomerular disease
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... ANCA-positive vasculitis ... polyangiitis, Microscopic ... ANCA-negative vasculitis ... #Syndrome #differential
Urinary Casts and Disease Associations Hyaline - May be nonspecific; seen in normal individuals or during severe
Disease Associations ... tubulointerstitial nephritis, renal ... Fatty - Nephrotic syndrome ... #Differential # ... Microscopy #Diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... • Sjögren syndrome ... : • Microscopic ... vasculitis - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... pulmonary and renal ... PR3-ANCA): • Microscopic ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Injury (AKI) - Differential ... at least 50% Renal ... • Hepatorenal syndromes ... Obstruction • Cast ... polyangiitis /microscopic
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... polyangiitis), MPA (microscopic ... FINDINGS: • U/A: microscopic ... hematuria, RBC casts ... #Syndromes #differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... cryocrystalglobulin GN -C3 GN • Cast ... Sneddon-Wilkinson disease ... vascular beds-renal ... Hematology #Monoclonal #Differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... pulmonary and renal ... Differential Diagnosis ... (PR3-ANCA)): Microscopic ... • Cogan syndrome
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