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Three Ds of Clinical Debriefing : Deactivation, Deconstruction and Dissemination 

- Dr. Ben Symon https://twitter.com/symon_ben

#Clinical #Debriefing
Three Ds of Clinical ... /symon_ben #Clinical ... #Debriefing #3Ds
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Aplastic Anemia ... vs Hypocellular MDS ... #Aplastic #Anemia
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypoproliferative Macrocytic Anemia ... Deficiency • MDS ... #Macrocytic #Anemia
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... Liver Disease, MDS ... iron deficiency anemia
Etiologies of pulmonary infections according to CT-scan patterns. 
CMV cytomegalovirus, GM galactomannan, HSV herpes simplex virus,
Etiologies of pulmonary ... simplex virus, MDS ... oxtvmJe1RmlxFFJpzgymkqdNRFOw%3D ... %3D #CT #Patterns ... #Pulmonary #Lung
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... ACD, Aplastic anemia ... Reticulocytosis, MDS ... MatthewHoMD #Anemia
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Clinical Presentation ... myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Severe hemolytic anemia ... Sideroblastic anemia ... , Hemolytic anemia ... , Sickle cell, MDS
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... megaloblastic anemia ... Can progress to MDS ... SCVMCMed #Aplastic #Anemia
Pulmonary Function Tests (PFTs) - Interpretation Algorithm
 • Normal
 • Pulmonary Hypertension, Anemia, Carboxyhemoglobinemia
 • Chest
Pulmonary Function ... • Normal • Pulmonary ... Hypertension, Anemia ... Emphysematous COPD #Pulmonary