21 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... common • Imaging: CXR ... - pulmonary opacities ... Diagnosis: >3 symptoms ... #management #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... Constitutional Syndromes ... • Improve the symptoms ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
manifestations, hypoxia, CXR ... - infiltrates (anemia ... smear: Blasts APML ... • Tumor lysis syndrome ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... blood count with differential ... progression to AML ... #diagnosis #hematology
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Pathogenesis and clinical ... Signs/Symptoms ... , sleep apnea, cor ... pulmonale #PraderWilli ... #pathophysiology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Pathogenesis and clinical ... - CHF - Pulmonary ... hemolysis - anemia ... #diagnosis #pathophysiology ... #symptoms #signs
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... ARDS to explain symptoms ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... of anemia include ... younger pts) Differential ... #hematology #diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... AP, ↑INR, ↑BUN/Cr ... infiltration) Differential ... Maternal Support - Critical
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... renal failure Clinical ... e.g. incidental CXR ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary