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diagnosis symptoms differential hematology management workup algorithm oncology physicalexam rheumatology abnormal acute aplastic deficiency erythematosus infections lupus mds myelodysplastic nutrition
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... (MDS) (normal or
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... • Symptomatic anemia ... megaloblastic anemia ... Can progress to MDS
What is a Boxer’s fracture?? Fracture of the 4th or 5th metacarpal neck - Common in
the 4th or 5th metacarpal ... over fractured metacarpal ... – compartment syndrome ... Overlying wounds or signs ... Fracture #Hand #Metacarpal
Clinical manifestations of acute liver failure Brain: Hepatic encephalopathy, Cerebral edema, Intracranial hypertension,
Hepatorenal syndrome ... Hepatoadrenal syndrome ... Hepatopulmonary syndrome ... suppression, Anemia ... liver #failure #Signs
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... Abnormalities: macrocytic anemia ... myelodysplastic syndrome ... (MDS) Most met ... (MDS) and/or
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(MDS) What? ... platelets) • MDS ... precursors MDS ... • Aplastic Anemia ... chemotherapy #MDS
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #MDS #Diagnosis
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
E - Haemolytic anaemia ... Wernicke-Korsakoff syndrome ... paraesthesiae • Folate - Anaemia ... Vitamin B12 - Anaemia ... differential #diagnosis #signs
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
HLH syndrome 5. ... Acquired Aplastic Anemia ... • Hypoplastic MDS ... marrow failure syndrome
Hypothyroidism – symptoms and signs. Symptoms: Tiredness/malaise, Weight gain, Anorexia, Cold intolerance, Poor memory, Change in appearance, Depression, Poor libido,
– symptoms and signs ... , Deafness Signs ... Carpal timel syndrome ... Slow-relaxing reflexes, Anaemia ... Hypothyroid #Features #Signs
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