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diagnosis differential hematology management algorithm iron nutrition oncology aplastic celiac disease erythematosus gastroenterology gca giantcell gravis lupus myasthenia myelodysplasia myelodysplastic
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Elite athletes • Chronic ... Loss (without anaemia ... ) #Iron #Deficiency
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... pylori, Celiac, Enteritis ... : Gl lesions / cancer ... Inflammation: IBD, Chronic ... #diagnosis #anemia
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
disease • Iron-deficiency ... anemia unresponsive ... to treatment ... without discernable cause ... Matthew Ho, MD
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... Treatment:
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes (MDS ... platelets) • MDS ... precursors MDS ... Marrow Failure • Chronic ... chemotherapy #MDS
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Malignancy: Metastatic cancer ... • Infections: Chronic
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
syndrome, rheumatoid arthritis ... distribution in the 30s ... test - Cogan sign ... - Peek sign ... inhibition - Chronic
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... systemic complaints- anemia ... of the steroid treatment ... Treatment of GCA ... GCA #Temporal #Signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
disease • Prolidase deficiency ... lymphopenia, low PLT • Anemia ... (C3 and C4) • ds-DNA ... with Lupus: • Chronic ... • Cervical cancer
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