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diagnosis hematology management chronic aplastic syndrome algorithm cll lymphocytic myelodysplastic acute cancer celiac cmml cnl dermatology disease erythematosus gastroenterology gravis
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... Zhuoer Xie, MD ... #Aplastic #Anemia ... #diagnosis #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... Can progress to MDS ... or acute leukemia ... diagnosis #management #treatment
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... #hematology #oncology
Chronic Myelomonocytic Leukemia (CMML) • Definition • DDx • Dx Tool and Risk Stratification • Treatment
Myelomonocytic Leukemia ... Stratification • Treatment ... Zhuoer Xie, MD ... Myelomonocytic #Leukemia ... #CMML #oncology
Chronic Neutrophilic Leukemia (CNL) • Signaling Pathway • WHO Dx Critera • Risk Stratification • Treatment
Chronic Neutrophilic Leukemia ... Stratification • Treatment ... Zhuoer Xie, MD ... #Neutrophilic #Leukemia ... #diagnosis #oncology
Mixed Phenotype Acute Leukemia (MPAL) - Summary • Bilineal MPAL vs. Biphenotypic MPAL • Genomic categories
Phenotype Acute Leukemia ... Immunophenotypes • Treatment ... Zhuoer Xie, MD ... Phenotype #Acute #Leukemia ... #diagnosis #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
myelodysplastic syndrome (MDS ... virus (EBV) • Leukemia ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... Treatment:
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Most common leukemia ... 5) Symptoms of anemia ... marrow failure with anemia ... Lauren Banaszak, MD ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... Physical Exam/Signs ... • Neutropenia, anemia ... microglobulin Treatment ... diagnosis #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes (MDS ... platelets) • MDS ... precursors MDS ... chemotherapy #MDS ... diagnosis #hematology #oncology
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