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anemia hemophagocytic hlh lymphohistiocytosis syndrome treatment apml arteritis bullous chronic cll dermatology differentiation disorders gca giantcell hematololgy hemeonc leukemia leukostasis
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Summary • Definition ... • Pathophysiology ... #Anemia #diagnosis ... #oncology #hematololgy
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... and symptoms: ... #management #treatment ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Improve the symptoms ... #Anemia #oncology ... #hematology #diagnosis ... #management
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Disorders (PTLD) Definition ... , unexplained hematologic ... EBV viral load, signs ... Lymphoproliferative #Disorders #oncology ... #diagnosis #management
Bullous Pemphigoid - Diagnosis and Management Summary Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Bullous Pemphigoid - Diagnosis ... Summary Pathophysiology ... dermis Clinical Signs ... /Symptoms/Exam findings ... #Management #dermatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... Syndrome #TLS #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH) Definition ... : HLH signs and ... symptoms can mimic ... #management #treatment ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... opacities • Diagnosis ... : >3 symptoms, or ... #management #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Pure red cell aplasia ... #workup #oncology ... #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
arteritis (GCA) definition ... systemic sx + signs ... GCA #Temporal #Signs ... #Symptoms #Diagnosis ... #Management
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