7 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Biliary Cirrhosis vs Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
• Female:Male 9: ... Pathophysiology ... Signs and Symptoms ... Labs: • Alkaline ... diagnosis #workup #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Highest • Bone • Liver ... Most common symptoms ... - Drugs - Primary ... biliary Cholangitis (PBC ... Diagnosis #Algorithm #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Tests - AST, ALT, Alkaline ... CAST) • ALT: primarily ... within liver Alkaline ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver ... collection with EDTA Pathophysiology ... mineralization Symptoms ... • Elevation of urinary ... Hyophosphatasia #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... DIC • Severe Liver ... Treatment: • Treat primary ... hydration • RBC ... treatment #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Types of HLH • Primary ... Common Signs and Symptoms ... - Elevated liver ... Pathophysiology ... Diagnosis #Management #Hematology