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rheumatology differential signs symptoms antibodies classification management pulmonary renal ana anca antibody antineutrophil antinuclear arthritis associations autoantibodies behcet causes cryoglobulinemia
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... La) - Sjogren's syndrome ... c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... #diagnosis #table
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... , anti-GBM ab, ANA ... #differential #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... : • Behçet Syndrome ... • Cogan Syndrome ... Differential Diagnosis ... LFT • ESR • ANA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... cases • Sjögren syndrome ... ANCA-Associated Vasculitis ... Renal-limited vasculitis ... Antineutrophil #antibodies #diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... panuveitis, retinal vasculitis ... ) Differential Diagnosis ... Glucocorticoids 5-ASA ... #diagnosis #management
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
endothelial injury and end-organ ... Hyperviscosity Syndrome ... • Autoimmune diseases ... Labs/Diagnosis: ... Cryoglobulins #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... polymorphisms alter ... galactose-deficient IgA1 (GD-IgA1 ... nephrotic/nephritic syndrome ... Pathophysiology #Diagnosis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal Syndromes ... Autoimmune ANCA vasculitis ... life-threatening diseases ... Inflammatory eye disease ... palpable purpura 2/2 vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... Erythematosus #Diagnosis
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
and Differential Diagnosis ... Coarctation of aorta, Vasculitis ... Renal parenchymal disease ... White-coat syndrome ... #Differential #Diagnosis
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