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causes differential dermatology hepatology pruritus treatment dili gastroenterology generalized product reactions secondary systemic acidosis aclf activation acute aplastic chronic cirrhosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Liver Injury (DILI ... #Liver #Injury ... #algorithm #gastroenterology ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Algorithm DILI ... toxic aetiology: Skin ... #Injury #Diagnosis ... #Algorithm #hepatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Algorithm - Systemic ... / Systemic == Blood ... • Cholestatic liver ... renal failure/uremia
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... Clinical Presentation ... Headaches • Pale skin ... result from low blood ... #diagnosis #management
Mild-to-Moderate Ulcerative Colitis - Management Algorithm Curcumin: • Natural phytochemical from turmeric • 2g/day divided in 2-3
Ulcerative Colitis - Management ... Potential GI SE, liver ... injury, inhibit ... Nissle • VSL#3: ↑ clinical ... Budesonide to induce
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... - Differential Diagnosis ... Algorithm Blood ... renal failure/uremia ... #generalized #dermatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
hypoperfusion - toxic-induced ... removal from the blood ... or renal injury ... 30mmHg) - Severe anemia ... Injury: • Reduced
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Sepsis • Drug-induced ... with leukopenia, anemia ... thrombocytopenia • Liver ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... organ damage Clinical ... DIC • Severe Liver ... #Coagulation #diagnosis ... #hematology
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