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differential causes hemolytic leukemia management aplastic chronic classification cll ddxof disorders eosinophil erythroderma gap globulin hemolysis hodgkins lymphocytic lymphoma macrocytic
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... , 500-1,500 cells ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Hemolysis #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Algorithm. ... cells. ... Exfoliative toxin 2) Eosinophils ... T-cells #Diagnosis ... #Dermatology #Rash
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Skin Ulcers by Etiology ... Algorithm Physical ... • Bleomycin Hematologic ... Anemia • Thalessemia ... ulcerative #skinrash #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Diagnosis: • ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... corpuscular (cell ... Red cell distribution ... #Algorithm #Diagnosis ... #Workup #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... cells - Consider ... #Algorithm #workup ... #hematology #testing
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... - Hepatitis, eosinophilic ... number of CD34+ cells ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... - infiltrates (anemia ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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