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rheumatology management differential druginduced dermatology erythematosus syndrome systemic activation anemia causes comparison dili eosinophil eosinophilia hemolytic hepatology injury liver macrophage
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus (DIL): ... NPSLE rare, Malar rash ... SCLE-DIL (terbinafine ... • Immunologic Workup ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar rash ... versus DIL • ... • Immunologic Workup ... life-threatening • Treatment
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... glucocorticoid treatment ... consider tissue biopsy ... #diagnosis #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Algorithm Pinpoint ... Vasculitis - Collagen disorders ... Autoimmune Vasculitis (lupus ... deficiency Work ... cryoglobulins • Skin biopsy
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... Malignancy (e.g. hematologic ... • Kidney biopsy ... Erythematosus #Diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... non-essential drug/HDS treatments ... Consider liver biopsy ... Hepatic vascular disorder ... #Algorithm #hepatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
NPSLE rare, Malar rash ... SCLE-DIL (terbinafine ... • Immunologic Workup ... #DIL #rheumatology ... #diagnosis #treatment
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... genotypes): SS, SC, SE ... Consider RBC membrane disorder ... #Algorithm #workup ... #hematology #testing
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... erythematosus [SLE ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Rare Disorder: ... , breast CA - Hematologic ... ’s syndrome - Lupus ... : - Biopsy - Microscopic ... Treatment: - Systemic
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