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rheumatology management differential dermatology druginduced erythematosus syndrome systemic activation causes comparison dil disease disorders eosinophilia igg4 macrophage oncology petechiae petechial
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
glucocorticoid treatment ... may be indicated ... consider tissue biopsy ... #Differential #diagnosis ... #hematology #eosinophilia
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar rash ... • Immunologic Workup ... life-threatening • Treatment ... Erythematosus #Diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... • Immunologic Workup ... • Immunologic Workup ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... Malignancy (e.g. hematologic ... • Kidney biopsy ... Erythematosus #Diagnosis
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential Diagnosis ... Algorithm Pinpoint ... Autoimmune Vasculitis (lupus ... deficiency Work ... cryoglobulins • Skin biopsy
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history: Man ... orientation, Biopsy ... phase reactants, eosinophilia ... management #phenotypes #workup ... #treatment #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... erythematosus [SLE ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... ’s syndrome - Lupus ... : - Biopsy - Microscopic ... Treatment: - Systemic
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... #DIL #rheumatology ... #diagnosis #treatment
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
SLE, atherosclerotic ... ESR > 50mm/hr • Biopsy ... , mucositis • Rash ... Polyangiitis): • Eosinophilia ... #Rheumatology
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