22 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... distal tubule. ↑ Nacl ... #Syndrome #Pathophysiology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Metabolic Alkalosis - Differential ... , Gitelman Syndrome ... , Liddle syndrome ... Metabolic #Alkalosis #Differential ... Diagnosis #Algorithm #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... acid, Liddle's Syndrome ... , Gitelman's syndrome ... #Hypokalemia #Differential ... Diagnosis #Algorithm #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ascending limb Gitelman ... tubule Liddle syndrome ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... , Gitelman Syndrome ... , Liddle syndrome ... Metabolic #Alkalosis #Differential ... Diagnosis #Algorithm #Nephrology
Gitelman Syndrome - Management
Treatment includes
 - Electrolyte replacement - K & Mg, preferably Cl salts
Gitelman Syndrome ... - Management Treatment ... Mg, preferably Cl ... #Syndrome #Management ... #Treatment #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... ratio 0.5%) Differential ... Rhabdomyolysis Treatment ... #nephrology #management ... #pathophysiology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
• Low Urine Cl ... • High Urine Cl ... , Gitelman syndrome ... urine #potassium #differential ... algorithm #diagnosis #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Hypochloremia - Differential ... - Bartter - Gitelman ... Hypochloremia #Differential ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Kidney loss of Cl ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... urine #Algorithm #nephrology ... #differential #