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hepatology differential causes lfts transaminitis management chronic aclf aih chemistry cirrhosis coagulation comparison deficiencies deficiency druginduced failure fatigue function gastroenterology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... Injury (DILI) ... gastroenterology #management #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Algorithm DILI ... hepatitis #DILI ... #Injury #Diagnosis ... #Algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... : Autoimmune hepatitis ... ALT Ratios: • Alcoholic ... #injury #hepatitis ... #algorithm #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... injury - Viral ... Hepatitis - Autoimmune ... #Differential #Hepatology ... #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... #hepatology #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... > 20x normal - Acute ... #Injury #hepatology ... #differential #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... Drugs (MDMA), Alcohol ... Other: NAFLD, Autoimmune ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Algorithm Malignant ... Non-Malignant • Fatty Liver ... Inflammatory • Alcoholic ... Hepatitis • Autoimmune ... #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... ALT Ratios: • Alcoholic ... #chemistry #diagnosis ... #differential #Hepatology
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