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differential hematology management rheumatology vasculitis apml chronic cll differentiation emergencies hemeonc hodgkins infectiousdiseases leukemia lymphocytic lymphoma manifestations mds mycobacteria myelodysplasia
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
Reconstitution Inflammatory Syndrome ... lymphadenopathy, pulmonary ... Children with pulmonary ... and not direct infection ... #Tuberculosis #diagnosis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... Renal Syndromes ... mononeuritis multiplex WORKUP ... confirm DAH, r/o infection ... or serologies + symptoms
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... disorder (Cardiac, pulmonary ... dystrophies Work ... #Differential #Diagnosis ... #neurology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Lady Windermere Syndrome ... : • Syndrome of ... Growers (Runyon Classification ... gastrointestinal symptoms ... • Clinical (Symptoms
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
if SSTI or port infection ... work-up - If febrile ... days → add fungal work-up ... renal failure, pulmonary ... #HemeOnc #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... : Infection (sepsis ... management #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... weeks without infection ... phenomenon CLL Diagnosis ... • Richter’s Syndrome ... #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Presentation: Systemic Symptoms ... affects the skin, neurologic ... • Progressive symptoms ... cognitive impairment, neurologic
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... ingestion • B symptoms ... Hodgkin Lymphoma Workup ... #classification ... #hematology #oncology
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