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treatment hemophagocytic hlh lymphohistiocytosis oncology stills adultonset aosd blood chronic cll differential hemeonc leukemia lupus lymphocytic product reactions sle summary
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... Differential Diaqnoses ... #diagnosis #management ... #treatment #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... bartonella (oroya fever ... #Differential #Diagnosis ... #Algorithm #workup ... #hematology #testing
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... (KD) - Diagnosis ... Presentation: • Fever ... Criteria - Fever ... KD #vasculitis #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... : High spiking fever ... Systemic AOSD: high fever ... #AOSD #rheumatology ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... • Immunologic Workup ... Evolution: Chronic disease ... Erythematosus #Diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Periodic fever ... - Nonremitting fever ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... screening for disease ... with established disease ... Avoid meds that ... #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... • Leukocytosis Diagnosis ... #AOSD #diagnosis ... #rheumatology # ... management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... IgG4 #Related #Disease ... #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... • Autoimmune diseases ... Adult-onset Still disease ... #management #treatment ... #summary #rheumatology
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