11 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Anticoagulant Sites of Action ... #Medications #Pharmacology ... #Pathophysiology ... #Mechanisms #DOAC
Class I Antiarrhythmics and their Key Pharmacologic Properties

Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer")
Class IB
and their Key Pharmacologic ... This type of action ... ) due to their actions ... #Pharmacology # ... Agents #Cardiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
, Intermediate Action ... inotropy) ACCP Cardiology ... Vaughan #Williams #Pharmacology ... #pathophysiology ... #cardiology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... binding to its active ... #Pharmacology #Pathophysiology ... Heparins #LMWH #UFH #DOAC ... #Fondaparinux #NOAC
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
Classification Class ... Widens QRS complex Class ... prolongs PR interval Class ... Blockade • Prolongs action ... #cardiology #pharmacology
Drugs affecting the cardiac action potential. The sharp rise in voltage ("0") corresponds to the influx
affecting the cardiac action ... #Pathophys #Pharmacology ... #Cardiology #Antiarrhythmics ... #Classes #Effect
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... inotropy) ACCP Cardiology ... Antiarrhythmics #Pharmacology ... #pathophysiology ... #phases #cardiology
Acute Atrial Fibrillation - Initial Options for Rate Control
Diltiazem IV
 •  Rapid onset and rapidly
most effective option ... regimen is not as clear ... Slowest onset of action ... Rate #Control #pharmacology ... #management #cardiology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... intracellular calcium causes ... #Pathophysiology ... #cardiology
Medications Used in Congestive Heart Failure

In CHF, the heart is failing as a pump; cardiac output
CHF also causes ... #Pharmacology #CHF ... #Medications #Action ... #HeartFailure #Cardiology