31 results
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
clinically) and asthma ... /eosinophils No ... Inflammation: • No Asthma ... (GPA) • Both asthma ... #differential #diagnosis
Eosinophilic Pneumonia
When to suspect Eosinophilic Pneumonia? Non-resolving pneumonia + BAL > 25% eosinophils + excluded more
excluded more common diagnoses ... Effusions - Rare Peripheral ... tobacco hx, >60% asthma ... edema" - Common Peripheral ... #Pneumonia #diagnosis
Biologic therapy for eosinophilic asthma 
• Mepolizumab (Nucala) 
  • Anti-lL-5, 100 mg SQ q4
asthma • Mepolizumab ... q4 weeks • Peripheral ... q4 weeks • Peripheral ... q8 weeks • Peripheral ... #asthma #Biologic
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
45yo, F; Hx of asthma ... SOB, sinusitis, wheezing ... Weeks) - Hx of asthma ... food hx; Fever, wheezing ... #differential #diagnosis
First-line therapies for Asthma, Asthma-COPD Overlap and COPD

The diagnosis of COPD, asthma, and ACO initially requires
and COPD The diagnosis ... , and ACO initially ... analysis with eosinophil ... ACO = asthma-COPD ... #Diagnosis #Management
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... FOR TESTING: • Peripheral ... blood eosinophilia ... common causes are asthma ... #Differential #diagnosis
Causes of Pediatric Wheezing - Differential Diagnosis Algorithm
CXR Abnormal:
 • Pulmonary Sequestration
 • Congenital Adenoid Cystic
Causes of Pediatric Wheezing ... - Differential Diagnosis ... Beta-Agonist: • Asthma ... #Differential #Diagnosis ... Algorithm #Causes #Peds
The infant with tachypnea or wheeze - Clinical Conditions to Consider
 - Bronchiolitis 
 - Pneumonia
Transient early wheezing ... infection - Atopic asthma ... — recurrent wheezing ... Other causes #Diagnosis ... #Peds #Pediatrics
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Diagnosis Algorithm ... Primary Eosinophilia ... histiocytosis • Allergic: Asthma ... #Differential #Diagnosis
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential Diagnosis ... DRESS - AIN - Eosinophilic ... Dermatitis - Asthma ... #Differential #Diagnosis