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rheumatology diagnosis management acr2021 algorithm vasculitis guidelines treatment pharmacology acr arteritis criteria granulomatosis polyangiitis classification differential erythematosus gravis lupus myasthenia
Central Nervous System Pharmacology - Somatic and Autonomic Receptors Somatic • Rocuronium -> Non-depolarizing (reversible competitive inhibitors)
blocks action AchE ... the levels of Ach ... and Digest” - Ach ... Fight or Flight” - Ach ... Adrenal Medulla - Ach
Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
of generalized AChR-MG ... muscle-specificreceptortyrosinekinase #AChR
A toxidrome is a syndrome (set of symptoms) caused by specific medications or toxins. There are 5
antipsychotics, oxybutynin, ACh ... - Cholinergic: ACh
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Ab to AChR blocks ... Labs: - AchR antibodies
Ice-pack Test for Myasthenia Gravis - Likelihood Ratio (LR) +24 / -0.16 Ice pack's can be used
effectively increasing ACh
Intern Pocket Cards - Inpatient Anti-Emetics Guide Serotonin antagonists: • Ondansetron (Zofran), Granisetron (Kytril, Sancuso) - Headache,
paradoxical excitation ACh ... DA/Histamine/ACh
First Generation Anti-Psychotics: Mechanisms and Side Effects Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine ACh M1 antagonist - Block
Chlorpromazine ACh ... Block action of ACh
Varicocele: Pathogenesis and clinical findings Primary: - Anatomically: the left spermatic vein drains into the left renal
Primary varicocele ache
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Antagonism - Block ACh
Ocular Myasthenia Gravis on Physical Exam A 41yo female was referred by her neurologist for double vision.
suspected and anti-ACh
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