56 results
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Workup Blood Work ... Fractional excretion of Cl ... dr_missyhanna #Gitelman ... #Workup #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
- Differential Diagnosis ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #Differential #Diagnosis ... #Algorithm #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Epithelial Cells Renal ... ascending limb Gitelman ... receptor Distal renal ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
- Differential Diagnosis ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #Differential #Diagnosis ... #Algorithm #Nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
- Differential Diagnosis ... Renal Causes of ... Bartter syndrome and Gitelman ... #differential #diagnosis ... #causes #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
- Differential Diagnosis ... Algorithm Extra-renal ... loss (Diarrhea) Renal ... Bartter syndrome, Gitelman ... potassium #low #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology Gitelman ... autosomal recessive salt-losing ... Pathophysiology #nephrology ... #diagnosis
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Workup Algorithm ... mOsm/kg - Implies renal ... Hypervolemic (Excess salt ... #nephrology #sodium
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
diarrhea / IBD Renal ... - Familial renal ... syndromes - Gitelman ... #Differential #Diagnosis ... Classification #Causes #Workup
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Hypernatremia Diagnosis ... and Workup Step ... Hypernatremia #Diagnosis ... #Workup #Algorithm ... #Nephrology