35 results
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
limb Gitelman syndrome ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
- Differential Diagnosis ... cirrhosis, nephrotic syndrome ... Nausea, Pulmonary Diseases ... , CNS Disease, Meds ... #nephrology #sodium
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
Cirrhosis, Nephrotic syndrome ... osmostat, Cerebral salt ... Hyponatremia #Algorithm #diagnosis ... #sodium #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... autosomal recessive salt-losing ... thiazide-sensitive sodium-chloride ... Pathophysiology #nephrology ... #diagnosis
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Hypervolemic (Excess salt ... , Cushing syndrome ... Workup #Algorithm #nephrology ... #sodium
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
: Arterial (MCC-small ... Medium and large ... artery aneurysms Diagnosis ... ) Differential Diagnosis ... #diagnosis #management
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
losses, Cerebral salt ... Cirrhosis, Nephrotic syndrome ... Hyponatremia #algorithm #diagnosis ... #sodium #low #nephrology
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
Always start with ... demyelination syndrome ... vaptans (HF/liver disease ... #Treatment #management ... #nephrology #sodium
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... the excretion of sodium ... urine #Algorithm #nephrology ... #differential #diagnosis
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
: SIADH, Renal Sodium ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... #table #sodium ... #nephrology