1555 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
ALP enzyme- Discovered ... in 1923 Low ALP ... 1948 by Rathbun ALP ... Neuropathy ALP ... collection with EDTA Pathophysiology
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
• Incr serum ALP ... PagetsDisease #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... Nucleotidase • ALT ... obstruction • ALP
Rickets and Osteomalacia: Pathogenesis and Clinical Findings
 • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
enzymes (like ALP ... #Osteomalacia #pathophysiology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
phos/ULN ALP) ... Cholestasis • ALP ... disease • If ALP ... both are normal - ALP ... • Elevation of ALP
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
or AST > ALP): ... • Severe - ALT ... • Moderate - ALT ... Cholestatic Pattern (ALP ... > ALT or AST):
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Natriuretic Peptides - Pathophysiology
 • Brain Natriuretic Peptide (BNP)
 • Atrial Natriuretic Peptide (ANP)
 • N-terminal
Natriuretic Peptides - Pathophysiology ... Natriuretic Peptide (ANP ... BNP #NTproBNP #ANP ... #cardiology #Pathophysiology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... ) Pathophysiology ... Findings: • ↑AST/ALT ... , ↑Tbili/Dbili/AP ... diagnosis #management #pathophysiology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
specificity to elevated ALP ... • AST/ALT > ALP ... GGT/5-NT: ↑ - ALP ... disease - If ALP ... hemolysis) • ALP