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diagnosis management hematology barre cancer differential tls tumor aki apml classification differentiation emergencies encephalopathy gbs guillainbarre injury kidney leukemia nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... Pathophysiology: ... : - Neuro: AMS ... , AKI, acute limb ... Syndrome: • Pathophysiology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... of breath • Neurologic ... Leukostasis: • ... EMERGENCIES: Tumor Lysis ... Hyperuricemia • Acute
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... - Summary Acute ... Pathophysiology ... variants: (1) acute ... #neurology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... An acute, life-threatening ... grade lymphoma & Acute ... #Syndrome #TLS ... #oncology #management
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... malignancies Treatment ... Interleukin-2) • Tumor lysis ... #AKI #Cancer #Oncology ... Classification #Nephrology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
↑ Can develop leukostasis ... syndrome: CNS manifestations ... & DIC • Tumor lysis ... syndrome: Develops ... Leukemia #Hematology #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... coagulopathy, RRT/IMV as ... management #hematology #oncology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... (GBS) Acute autoimmune ... the underlying pathophysiology ... and cauda equina TREATMENT ... diagnosis #management #neurology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Etiology: • Pathophysiology ... edema visualized as ... , ADEM, Acute toxic ... epilepticus Treatment
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