47 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... Signs of anemia ... Abnormal peripheral smear ... Differential #Diagnosis #Algorithm
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical ... #Smear
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... peripheral blood smear ... In addition to APL ... #Clinical #Path ... BloodSmear #Blood #Smear
Megaloblastic Anemia vs Normal Peripheral Smear

#Megaloblastic #Anemia #Peripheral #Smear #Comparison #Clinical #Hypersegmented #Neutrophil
Megaloblastic Anemia ... Normal Peripheral Smear ... Megaloblastic #Anemia ... #Peripheral #Smear ... #Comparison #Clinical
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... Megaloblastic Anemia ... Peripheral #Blood #Smear ... interpretation #clinical ... #anemia
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Differential Diagnosis Algorithm ... Normochromic RBCs on Smear ... Spherocytes on Smear ... Differential #Diagnosis #Algorithm
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
metaplasia, pernicious anemia ... some hemolytic anemias ... #Clinical #Path ... BloodSmear #Blood #Smear
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Peripheral blood smear ... → Sickle Cell anemia ... Differential #Diagnosis #Algorithm
Elliptocyte - 
Note the shape of these appropriately named erythrocytes.
In addition to hereditary elliptocytosis, elliptocytes can
megaloblastic anemia ... myelophthisic anemia ... sideroblastic anemia ... #Clinical #Path ... BloodSmear #Blood #Smear
Sickle cell anemia and Howell Jolly bodies (nuclear remnants).

 - Dr. Abubaker Elshaikh
@ElshaikhMD

#SickleCell #HowellJolly #Body #Bodies
Sickle cell anemia ... Pathology #Hematology #Smear ... #Clinical #Microscopy