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diagnosis management antidrugantibodies antitnffailure causes checkpointinhibitor differential druglevels gibleed immune lower resistance upper
Upper and Lower Causes of GI Bleed Upper: • Esophagus: Tear (Mallory Weiss, Boerhaave syndrome), Variceal, Esophagitis,
Lower Causes of GI ... , Infectious colitis ... , UC/Chrons (IBD ... Radiation CMC IM ... diagnosis #Causes #algorithm
Algorithm for managing the failure of anti-TNF therapy. ADA=anti-drug antibody; IM=immunomodulator; MOA=mechanism of action; TNF=tumor necrosis
Algorithm for managing ... factor #Management #GI ... #IM #IBD #AntiTNFFailure ... AntiDrugAntibodies #DrugLevels #Algorithm ... #BMJ
Immune Checkpoint Inhibitor-Mediated Colitis Grade of Disease Severity: • G1: Increase < 4 BMs/day over baseline; mild
Inhibitor-Mediated Colitis ... indicated Diagnostic Evaluation ... -4 • Consult GI ... diagnosis #management #algorithm ... #IBD
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