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cardiology hfref management gdmt diagnosis em failure guideline heart heartfailure pharmacology ace allergy angioedema angiotensin angiotensinreceptorblockers angiotensinreceptorneprilysininhibitor arb bradykinin bumetanide
HFrEF: Guideline Directed Medical Therapy "Must Be On" • ACEI, ARB, or ARNI AND select Beta Blockers
Must Be On" • ACEI ... , ARB, or ARNI AND ... Reducing: • ACEI ... or ARB • ARNI ... #medications #chf
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy - Initiation Strategies •
Stepwise Approach: ACE ... , ARB, ARNI → Beta-Blocker ... -2 Inhibitor → ARNI ... Heart #Failure #CHF
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy • Beta-blocker • ACE,
Beta-blocker • ACE ... , ARB, ARNI • ... Heart #Failure #CHF
Guidelines Directed medical therapy for Heart Failure Satyendra Dhar, MD, @DharSaty #HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
AngiotensinReceptorNeprilysinInhibitor #ACEi ... angiotensinreceptorblockers #ARB #ARNI ... #PARADIGM-HF #EMPEROR-Reduced
Target Doses in Congestive Heart Failure • Beta Blockers: Bisoprolol, Carvedilol, Metoprolol succinate, ARNI, Sacubitril/valsartan •
Metoprolol succinate, ARNI ... Sacubitril/valsartan • ACEI ... #HeartFailure #CHF
Pathophysiology of ACE inhibitor-induced angioedema: Angioedema is a vascular reaction associated with tissue (subcutaneous, submucosal) edema
Pathophysiology of ACE ... substances in ACE ... the presence of ACE ... #Pathophys #EM # ... #Angiotensin #Ddxof
Heart failure with Reduced Ejection Fraction (HFrEF) Clinical Presentation 1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
81% for acute HF ... 5 pts w/ acute HF ... Pharmacology: • ACE ... Inhibitors and ARBs • ARNIs ... #pharmacology #sCHF
Serious Bacterial Illness (SBI): 1) UTI and pyelonephritis Most common cause of SBI Accounts for 3-8% of uncharacterized fevers Female
Consider BCx, CSF ... Diagnosis #Peds #EM ... SeriousBacterialIllness #Ddxof
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
May have typical HF ... • Avoid ARB/ACE-I ... /ARNI/MRA • Avoid ... GDMT meds (e.g., ACE
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