1041 results
Target Doses in Congestive Heart Failure
 • Beta Blockers: Bisoprolol, Carvedilol, Metoprolol succinate, ARNI, Sacubitril/valsartan
 •
Metoprolol succinate, ARNI ... Sacubitril/valsartan • ACEI ... HeartFailure #CHF #pharmacology
Guideline-Directed Medical Therapy (GDMT) in HFrEF and CKD

 • Class I pillars of HFrEF GDMT across
kidney disease: ACEI ... , ARB, ARNI, BBs ... HFrEF #management #pharmacology
Heart failure with Reduced Ejection Fraction (HFrEF)
Clinical Presentation
1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
endomyocardial biopsy Pharmacology ... : • ACE Inhibitors ... and ARBs • ARNIs ... management #cardiology #pharmacology
HFrEF: Guideline Directed Medical Therapy

"Must Be On"
 • ACEI, ARB, or ARNI AND select Beta Blockers
Must Be On" • ACEI ... , ARB, or ARNI AND ... before increasing ACEI ... Reducing: • ACEI ... or ARB • ARNI
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
ACEI Antihypertensive ... the following ACEIs ... #ACEInhibitor #ACEIs ... Dosing #Conversion #Pharmacology
Guidelines Directed medical therapy for Heart Failure 

Satyendra Dhar, MD, @DharSaty

#HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
AngiotensinReceptorNeprilysinInhibitor #ACEi ... angiotensinreceptorblockers #ARB #ARNI
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy - Initiation Strategies

 •
Stepwise Approach: ACE ... , ARB, ARNI → Beta-Blocker ... -2 Inhibitor → ARNI
Lisinopril - ACE inhibitor used for the treatment of hypertension and heart failure. 3rd most prescribed
Lisinopril - ACE ... #Pharmacology #Lisinopril ... Prinivil #Qbrelis #ACEI
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy
 • Beta-blocker
 • ACE,
Beta-blocker • ACE ... , ARB, ARNI
NSAID vs ACEI/ARB effects on the Kidneys

Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
NSAID vs ACEI/ARB ... that NSAIDs and ACEI ... ACEI/ARB's are often