409 results
Acute Mountain Sickness 
Low partial pressure of oxygen at high altitude 
• Stop ascent 
• Supportive
oxygen at high altitude ... fluids, analgesia, ani ... Diagnosis #Management #Altitude
Medications for High-Altitude Sickness 
Acetazolarnide 
 • Carbonic Anydrase Inhibitor Bicarb diuresis & metabolic Acidosis ->
Medications for High-Altitude ... Decrease vasogenic edema ... #HighAltitude #Altitude
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy - Initiation Strategies

 •
Approach: ACE, ARB, ARNI ... -2 Inhibitor → ARNI
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Noncardiogenic Pulmonary Edema ... Noncardiogenic pulmonary edema ... of peripheral edema ... • High altitude ... pulmonary edema
HFrEF: Guideline Directed Medical Therapy

"Must Be On"
 • ACEI, ARB, or ARNI AND select Beta Blockers
ACEI, ARB, or ARNI ... ACEI or ARB • ARNI
Altitude Sickness: Acute Mountain Sickness (AMS), High Altitude Cerebral Edema (HACE) and High Altitude Pulmonary Edema
Altitude Sickness ... Sickness (AMS), High Altitude ... Cerebral Edema ... HACE) and High Altitude ... Pulmonary Edema
Differential Diagnosis: Cyanosis - Mnemonic "COLD PALMS"
Peripheral cyanosis 
• Cold 
• Obstruction 
• LVF and shock
Polycythemia • Altitude
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy
 • Beta-blocker
 • ACE,
• ACE, ARB, ARNI
Guidelines Directed medical therapy for Heart Failure 

Satyendra Dhar, MD, @DharSaty

#HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
angiotensinreceptorblockers #ARB #ARNI
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
2,3-BPG • High Altitude