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hematology cardiology algorithm anemia causes agglutinin cold dehydrogenase disease elevated framework infections infectiousdiseases intermittent laboratory lactate ldh management nonpalpable palpable
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
Leaflet: Rheumatic fever ... • Prosthetic valve ... annulus valve: ... Regurgitation #differential ... #diagnosis #cardiology
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... Acute bacterial endocarditis ... with profound hemolysis ... #Patterns #Differential ... #Diagnosis #intermittent
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... mechanical cardiac valve ... bartonella (oroya fever ... #workup #hematology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... night sweats, fever ... Marantic (NTBE) Differential ... Persistent bacteremia/fevers ... #Endocarditis #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Diagnosis Framework ... quinine, etc) - Viral ... - Mechanical: valve ... replacement, endocarditis ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... mountain spotted fever ... • Bacterial endocarditis ... #Diagnosis #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... - Prosthetic valves ... myocarditis, rheumatic fever ... #diagnosis #Laboratory
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Polyclonal - Viral ... Diagnosis: • hemolytic ... younger pts) Differential ... Symptoms: High fevers ... #anemia #hematology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
and Differential ... involves aortic and mitral ... night sweats, fever ... Persistent bacteremia/fevers ... #Endocarditis #Differential
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... Diagnosis Algorithm ... Red Flags: • Fever ... Schonlein Purpura - Endocarditis ... #Causes #dermatology
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