12 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
in the distal tubule ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... Pathophysiology #nephrology ... #diagnosis
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... Pressure: - Metabolic ... Hippurate - Metabolic ... #diagnosis #Algorithm ... differential #potassium #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Kidney ... Cl- outside the kidneys ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential #diagnosis
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Non-anion Gap Metabolic ... Chronic progressive kidney ... aniongap #NonGap #Metabolic ... #differential #diagnosis ... #causes #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... Heat stroke - Metabolic ... nephrotoxicity to kidney ... #Differential #Diagnosis ... #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... Hypochloremic metabolic ... Rhabdomyolysis Treatment ... Gitelman #Syndrome #diagnosis ... #nephrology #management
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Calcium 2-3g IV Ca-gluconate ... definitive guide to diagnosis ... #Diagnosis #Management ... #nephrology #K
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Obstructive uropathy, Metabolic ... causes (e.g., hypokalemia ... Treatment is aimed ... Classification #Types #Nephrology ... #Diagnosis #Differential
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Blood Work: - Hypokalemia ... Hypomagnesemia - Metabolic ... autosomal dominant kidney ... of echogenic kidneys ... #Workup #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
resistance • Metabolic ... disequilibrium syndrome • Diagnosis ... insipidus • Kidney ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology