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nephrology diagnosis differential algorithm causes low alkalosis metabolic urine chloride defects fanconi liddle localization management nephron urinary
Localization of Renal Tubular Defects Fanconi Syndrome: Proximal tubule Bartter Syndrome: Thick ascending loop of Henle Gitelman Syndrome: Distal
Bartter Syndrome ... loop of Henle Gitelman ... #Fanconi #Bartter ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... (renal potassium ... • Bartter syndrome ... • Pseudo Bartter-Gitelman ... #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... thiazide diuretics, Bartter ... syndrome, Gitelman ... Algorithm #causes #potassium ... #low #nephrology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... H+ secretion → Hypokalemia ... #Syndrome #Pathophysiology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... Mg2+ deficiency, Bartter ... syndrome, Gitelman ... syndrome #hypokalemia ... #urine #potassium
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... Emesis, Diuretics, Bartter ... syndrome, Gitelman ... #differential #potassium ... #nephrology #low
Causes of Hypokalemia - Differential Diagnosis Algorithm Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... • Diuretics, Bartter's ... syndrome, Gitelman's ... algorithm #causes #nephrology ... #potassium
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... h - Diuretics, Bartter's ... syndrome, Gitelman's ... syndrome #Hypokalemia ... #causes #low #potassium
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
indicates a renal tubule ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... other • Severe potassium ... Diagnosis #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
diuretic use, Bartter ... syndrome, Gitelman ... syndrome, Hypomagnesemia ... in the proximal tubule ... of sodium and potassium
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