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diagnosis differential classification hematology pathophysiology acute aki algorithm arterial cryofibrinogenemia cryoglobulinemia cryoglobulins embolism henochscholeinpurpura hsp iga kidney nephrology signs symptoms
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... causing endothelial injury ... • They can cause ... Cryoglobulins Cause ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... tract, and often causes ... - GI tract: abdominal ... Supply gut -> abdominal ... differential #diagnosis #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... osmolarity If cause ... Glomerulonephritis / Vasculits ... hepatitis serology, HIV ... renal biopsy • Abdominal
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
adhesion of IgA complexes ... Formation of immune complexes ... 85%) - Colicky abdominal ... nephrotic/nephritic syndrome ... and ankles) #HSP
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
of shoulder and hip ... pauci-immune GN Immune Complex ... tract, and often causes ... gut involvement, abdominal ... Differential #Diagnosis #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... cryoglobulins • Negative causes ... • TTP, HUS and HIT ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hematological: - HIT ... • Nephrotic Syndrome ... coagulation and other causes ... 19 - PNH - Vasculitis ... • Injury •
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