15 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... intravascular coagulation (DIC ... #Causes #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #Causes #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... • Severe Liver ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... glycogen stores - Prolonged ... As a result of DIC ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
regarding the diagnosis ... <45% and SF is normal ... If other causes ... hemochromatosis #algorithm #diagnosis ... #management #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... rapidly develops (DIC ... ) Differential Diagnosis ... #Pregnancy #hepatology ... obstetrics #obgyn #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
- Differential Diagnosis ... the PT remains prolonged ... discern these causes ... disease • Acute DIC ... #Hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
and Management ... disease) • aPTT is prolonged ... in mild cases) ... Chronic Management ... #hematology
Portopulmonary Hypertension
Presence of pulmonary arterial hypertension in a patient with portal hypertension
No other obvious causes (chronic
other obvious causes ... Transthoracic echocardiogram ... - Mechanism: causes ... hemodynamics Liver ... #management #hepatology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
and Management ... anterior/posterior MSK ... heart (2-5%), liver ... (pain/abnormal ... #Management #Signs