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differential hematology management signs algorithm hepatitis lfts aflp ankle apml biliary caudaequina cecs chemistry cholangitis chronicexertional cirrhosis clinical comparison compartmentsyndrome
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hyperbilirubinemia syndrome ... of about 30% of normal ... of hemolysis or liver ... examination; nonspecific symptoms ... #hepatology #diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
fold elevation, Bilirubin ... necrosis HELLP Syndrome ... fold elevation, Bilirubin ... Disease #Pregnancy #hepatology ... #differential #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... vein: Budd-chiari syndrome ... function may be abnormal ... • Gilbert's syndrome ... #algorithm #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
and unconjugated bilirubin ... and excretion of bilirubin ... the hepatorenal syndrome ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Defects, Drugs, Liver ... Blood Smear ↑ abnormal ... - Unconjugated Bilirubin ... #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
week • Direct bilirubin ... Elevation: • Bilirubin ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... PBC Signs and Symptoms ... slightly elevated • Bilirubin ... or higher • Liver ... #workup #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... suspicious clinical symptoms ... presence of metabolic syndrome ... Areas of diagnostic ... #Algorithm #Hepatology
Posterior Ankle Impingement (Os Trigonum) Syndrome - MSK Radiology Imaging Findings: • Os trigonum which has marrow
(Os Trigonum) Syndrome ... - MSK Radiology ... , os trigonum, abnormal ... flexion but no symptoms ... #diagnosis #msk
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... spine Signs / Symptoms ... Areflexia (loss of normal ... #MSK #pathophysiology ... #diagnosis #symptoms
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